Eosinophilic Pleural Effusion Induced by Paliperidone Palmitate: Case Report and Literature Review

• Published in: Journal of the Academy of Consultation-Liaison Psychiatry Vol. 63; no. 4; pp. 394 - 399
• Main Authors: de Ghellinck, Léopold, Frusch, Nicolas, Duysinx, Bernard
• Format: Journal Article Web Resource
• Language: English
• Published: Netherlands Elsevier Inc 01-07-2022
• Subjects: Cardiovascular & respiratory systems; case report; drug-induced eosinophilic pleural effusion; Eosinophilia/chemically induced/complications; eosinophilic pleural effusion; Exudates and Transudates; Human health sciences; Humans; iatrogenic pleural effusion; Leukocyte Count; paliperidone palmitate; Paliperidone Palmitate/adverse effects; Pleural Effusion/chemically induced/complications/diagnosis; R8P8USM8FR (Paliperidone Palmitate); Sciences de la santé humaine; Systèmes cardiovasculaire & respiratoire; case report; eosinophilic pleural effusion; iatrogenic pleural effusion; paliperidone palmitate; drug-induced eosinophilic pleural effusion
• ISSN: 2667-2960; 2667-2979; 2667-2960
• DOI: 10.1016/j.jaclp.2022.02.010

Eosinophilic pleural effusions are defined by an eosinophil count ≥ 10% in pleural fluid and represent approximately 10% of exudative pleural effusions. They are associated with a large spectrum of etiologies, both benign and malignant. Drug-induced eosinophilic pleural effusions remain rarely described.
After ruling out other causes with a careful diagnostic assessment, we retain paliperidone as the etiology, given the disappearance of the pleural effusion after drug discontinuation.
We report the first case of eosinophilic pleural effusion induced by paliperidone palmitate treatment.
After considering other etiologies, drug-induced eosinophilic pleural effusion should be sought.