Total knee arthroplasty in hemophilia A
Hemophilia A is a rare genetic disorder involving a deficiency of clotting factor VIII. Coagulation factor replacement therapy has prolonged the life expectancy of patients with hemophilia, but recurrent hemarthrosis of major joints is often a common occurrence. Therefore, orthopaedic adult reconstr...
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| Published in: | Arthroplasty today Vol. 6; no. 1; pp. 52 - 58.e1 |
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| Main Authors: | , , , , , , |
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| Abstract | Hemophilia A is a rare genetic disorder involving a deficiency of clotting factor VIII. Coagulation factor replacement therapy has prolonged the life expectancy of patients with hemophilia, but recurrent hemarthrosis of major joints is often a common occurrence. Therefore, orthopaedic adult reconstructive surgeons increasingly encounter hemophilic arthropathy in young adults and consider treating with total joint arthroplasty. In this report, the authors describe a patient with hemophilia A and severe knee osteoarthritis, who was subsequently treated with primary total knee arthroplasty. This rare case is an opportunity to explore a variety of unique clinical scenarios specific to patients with hemophilia, including the maintenance of optimal factor VIII levels through clotting factor infusions and prevention of a venous thromboembolic event. |
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| AbstractList | Hemophilia A is a rare genetic disorder involving a deficiency of clotting factor VIII. Coagulation factor replacement therapy has prolonged the life expectancy of patients with hemophilia, but recurrent hemarthrosis of major joints is often a common occurrence. Therefore, orthopaedic adult reconstructive surgeons increasingly encounter hemophilic arthropathy in young adults and consider treating with total joint arthroplasty. In this report, the authors describe a patient with hemophilia A and severe knee osteoarthritis, who was subsequently treated with primary total knee arthroplasty. This rare case is an opportunity to explore a variety of unique clinical scenarios specific to patients with hemophilia, including the maintenance of optimal factor VIII levels through clotting factor infusions and prevention of a venous thromboembolic event. Hemophilia A is a rare genetic disorder involving a deficiency of clotting factor VIII. Coagulation factor replacement therapy has prolonged the life expectancy of patients with hemophilia, but recurrent hemarthrosis of major joints is often a common occurrence. Therefore, orthopaedic adult reconstructive surgeons increasingly encounter hemophilic arthropathy in young adults and consider treating with total joint arthroplasty. In this report, the authors describe a patient with hemophilia A and severe knee osteoarthritis, who was subsequently treated with primary total knee arthroplasty. This rare case is an opportunity to explore a variety of unique clinical scenarios specific to patients with hemophilia, including the maintenance of optimal factor VIII levels through clotting factor infusions and prevention of a venous thromboembolic event. Keywords: Hemophilia A, Total knee arthroplasty, Factor VIII, Hemophilic arthropathy |
| Author | Rubin, Lee E. Charifa, Ahmad Pathak, Neil Laskin, William B. Kupfer, Gary M. Bisson, Emily Munger, Alana M. |
| AuthorAffiliation | c Department of Pediatric Hematology, Yale School of Medicine, New Haven, CT, USA a Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA b Department of Pathology, Yale School of Medicine, New Haven, CT, USA |
| AuthorAffiliation_xml | – name: b Department of Pathology, Yale School of Medicine, New Haven, CT, USA – name: c Department of Pediatric Hematology, Yale School of Medicine, New Haven, CT, USA – name: a Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA |
| Author_xml | – sequence: 1 givenname: Neil surname: Pathak fullname: Pathak, Neil organization: Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA – sequence: 2 givenname: Alana M. surname: Munger fullname: Munger, Alana M. email: dr.alana.munger@gmail.com organization: Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA – sequence: 3 givenname: Ahmad surname: Charifa fullname: Charifa, Ahmad organization: Department of Pathology, Yale School of Medicine, New Haven, CT, USA – sequence: 4 givenname: William B. surname: Laskin fullname: Laskin, William B. organization: Department of Pathology, Yale School of Medicine, New Haven, CT, USA – sequence: 5 givenname: Emily surname: Bisson fullname: Bisson, Emily organization: Department of Pediatric Hematology, Yale School of Medicine, New Haven, CT, USA – sequence: 6 givenname: Gary M. surname: Kupfer fullname: Kupfer, Gary M. organization: Department of Pediatric Hematology, Yale School of Medicine, New Haven, CT, USA – sequence: 7 givenname: Lee E. surname: Rubin fullname: Rubin, Lee E. organization: Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA |
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| CitedBy_id | crossref_primary_10_1016_j_arth_2024_03_004 crossref_primary_10_1016_j_artd_2021_04_010 crossref_primary_10_35339_ekm_2023_92_2_bas crossref_primary_10_1093_mr_roac067 crossref_primary_10_2174_1381612828666220418090928 crossref_primary_10_7759_cureus_29847 |
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| Keywords | Total knee arthroplasty Hemophilic arthropathy Hemophilia A Factor VIII |
| Language | English |
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| Title | Total knee arthroplasty in hemophilia A |
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