Total knee arthroplasty in hemophilia A

• Published in: Arthroplasty today Vol. 6; no. 1; pp. 52 - 58.e1
• Main Authors: Pathak, Neil, Munger, Alana M., Charifa, Ahmad, Laskin, William B., Bisson, Emily, Kupfer, Gary M., Rubin, Lee E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-03-2020; Elsevier
• Subjects: Arthroplasty in Patients with Rare Condition; Factor VIII; Hemophilia A; Hemophilic arthropathy; Total knee arthroplasty; Total knee arthroplasty; Hemophilic arthropathy; Hemophilia A; Factor VIII
• ISSN: 2352-3441; 2352-3441
• DOI: 10.1016/j.artd.2019.12.008

Hemophilia A is a rare genetic disorder involving a deficiency of clotting factor VIII. Coagulation factor replacement therapy has prolonged the life expectancy of patients with hemophilia, but recurrent hemarthrosis of major joints is often a common occurrence. Therefore, orthopaedic adult reconstructive surgeons increasingly encounter hemophilic arthropathy in young adults and consider treating with total joint arthroplasty. In this report, the authors describe a patient with hemophilia A and severe knee osteoarthritis, who was subsequently treated with primary total knee arthroplasty. This rare case is an opportunity to explore a variety of unique clinical scenarios specific to patients with hemophilia, including the maintenance of optimal factor VIII levels through clotting factor infusions and prevention of a venous thromboembolic event.