In vitro evaluation of alginate beads of a diclofenac salt

• Published in: International journal of pharmaceutics Vol. 163; no. 1; pp. 23 - 34
• Main Authors: Fernández-Hervás, M.J, Holgado, M.A, Fini, A, Fell, J.T
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 18-03-1998; Elsevier
• Subjects: Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Chitosan; Controlled release; Eudragit L30D; General pharmacology; Interpolymeric-complex; Medical sciences; Multiple unit-system; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Sodium alginate; Interpolymeric-complex; Sodium alginate; Chitosan; Multiple unit-system; Eudragit L30D; Controlled release; Methacrylate polymer; Pharmaceutical technology; Controlled release form; Molecular interaction; Alginates; In vitro; Diclofenac; Non steroidal antiinflammatory agent; Analgesic; Arylacetic acid derivatives; Dosage form; Active ingredient; Spherical particle; Release
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/S0378-5173(97)00333-5

Alginate beads containing diclofenac hydroxyethylpyrrolidine were formulated with either Eudragit or chitosan in order to achieve an enteric formulation. In all cases, high entrapment efficiencies were obtained. The examination of fractured beads revealed an internal void in the Eudragit–alginate beads. In contrast, a dense homogeneous internal structure was observed in the chitosan–alginate beads due to interpolymeric complex. An interaction between chitosan and drug was also observed. Under conditions mimicking those in the stomach, a small amount of drug was released. The alginate–chitosan beads showed a release behaviour dependent on pH value and alginate–chitosan ratio.