Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes

• Published in: Diabetologia Vol. 55; no. 10; pp. 2655 - 2659
• Main Authors: Yu, W., Ma, R. C., Hu, C., So, W. Y., Zhang, R., Wang, C., Tam, C. H., Ho, J. S., Lu, J., Jiang, F., Tang, S., Ng, M. C., Bao, Y., Xiang, K., Jia, W., Chan, J. C. N.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-10-2012; Springer; Springer Nature B.V
• Subjects: Alleles; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Body Mass Index; Case-Control Studies; China; Comorbidity; Diabetes; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Genotype; Glucose; Human Physiology; Humans; Incidence; Internal Medicine; KCNQ1 Potassium Channel - genetics; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Obesity; Obesity - epidemiology; Obesity - genetics; Overweight; Polymorphism; Polymorphism, Single Nucleotide - genetics; Regression analysis; Risk Factors; Short Communication; China; Hong Kong China; United States > US; Type 2 diabetes; Obesity; Han Chinese; Genetic variants; Endocrinopathy; Human; Nutrition disorder; Metabolic diseases; Variant; Association; KCNQ1; Chinese; Genetics; Nutritional status
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-012-2636-8

Aims/hypothesis
There is evidence of overlap between susceptibility loci for type 2 diabetes and obesity. The aim of this study is to explore the association between the established type 2 diabetes locus
KCNQ1
and obesity in Han Chinese.
Methods
We recruited 6,667 and 6,606 diabetic case–control samples from Shanghai and Hong Kong, respectively. Of the samples, 7.5% and 6.3% were excluded because of genotyping failure or data missing in the association analyses of rs2237892 and rs2237895 with obesity/BMI, respectively.
Results
We found that rs2237892 was associated with lower BMI and lower incidence of overweight/obesity in diabetic patients from Hong Kong (BMI, β = −0.0060 per diabetes risk C allele for log
10
BMI [95% CI −0.0088, −0.0032;
p
 = 2.83 × 10
−5
]; overweight/obesity, OR 0.880 for C allele [95% CI 0.807, 0.960;
p
 = 0.004]) and in the meta-analysis of cases from the two regions (BMI, combined β = −0.0048 per C allele for log
10
BMI [95% CI −0.0070, −0.0026;
p
 = 2.20 × 10
−5
]; overweight/obesity, combined OR 0.890 for C allele [95% CI 0.830, 0.955;
p
 = 0.001]). rs2237895 was also related to decreased BMI (combined β = −0.0042 per diabetes risk C allele for log
10
BMI [95% CI −0.0062, −0.0022;
p
 = 4.30 × 10
−5
]). A significant association with waist circumference was detected for rs2237892 in the pooled analyses (β = −0.0026 per C allele for log
10
[waist circumference] [95% CI −0.0045, −0.0007;
p
 = 0.007]). However, neither an association with the risk of being overweight or obese nor associations with quantitive traits were detected for rs2237892 or rs2237895 in controls.
Conclusion
Our findings indicate that
KCNQ1
is associated with obesity in Chinese patients with type 2 diabetes.