Cl - as a bona fide signaling ion

Cl is the major extracellular (Cl ) and intracellular (Cl ) anion whose concentration is actively regulated by multiple transporters. These transporters generate Cl gradients across the plasma membrane and between the cytoplasm and intracellular organelles. [Cl ] changes rapidly in response to cell...

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Bibliographic Details
Published in:	American Journal of Physiology: Cell Physiology Vol. 318; no. 1; p. C125
Main Authors:	Lüscher, Benjamin P, Vachel, Laura, Ohana, Ehud, Muallem, Shmuel
Format:	Journal Article
Language:	English
Published:	United States 01-01-2020
Subjects:	Animals Anion Exchange Protein 1, Erythrocyte - metabolism Anion Transport Proteins - genetics Anion Transport Proteins - metabolism Chlorides - metabolism Gene Expression Regulation Homeostasis Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Receptors, Purinergic P2X7 - metabolism Signal Transduction Sulfate Transporters - metabolism chloride signaling
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Summary:	Cl is the major extracellular (Cl ) and intracellular (Cl ) anion whose concentration is actively regulated by multiple transporters. These transporters generate Cl gradients across the plasma membrane and between the cytoplasm and intracellular organelles. [Cl ] changes rapidly in response to cell stimulation and influences many physiological functions, as well as cellular and systemic homeostasis. However, less appreciated is the signaling function of Cl . Cl interacts with multiple proteins to directly modify their activity. This review highlights the signaling function of Cl and argues that Cl is a bona fide signaling ion, a function deserving extensive exploration.
ISSN:	1522-1563
DOI:	10.1152/ajpcell.00354.2019