Arm and Intensity-Matched Leg Exercise Induce Similar Inflammatory Responses

• Published in: Medicine and science in sports and exercise Vol. 48; no. 6; pp. 1161 - 1168
• Main Authors: LEICHT, CHRISTOF A, PAULSON, THOMAS A W, GOOSEY-TOLFREY, VICTORIA L, BISHOP, NICOLETTE C
• Format: Journal Article
• Language: English
• Published: United States American College of Sports Medicine 01-06-2016
• Subjects: Adult; Arm - physiology; Chemokine CCL2 - blood; Epinephrine - blood; Exercise - physiology; Humans; Hydrocortisone - blood; Inflammation - blood; Inflammation - physiopathology; Interleukin 1 Receptor Antagonist Protein - blood; Interleukin-6 - blood; Leg - physiology; Leukocyte Count; Male; Monocytes - metabolism; Oxygen Consumption - physiology
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/MSS.0000000000000874

INTRODUCTIONThe amount of active muscle mass can influence the acute inflammatory response to exercise, associated with reduced risk for chronic disease. This may affect those restricted to upper body exercise, for example, due to injury or disability. The purpose of this study was to compare the inflammatory responses for arm exercise and intensity-matched leg exercise.
METHODSTwelve male individuals performed three 45-min constant load exercise trials after determination of peak oxygen uptake for arm exercise (V˙O2peak A) and cycling (V˙O2peak C)1) arm cranking exercise at 60% V˙O2peak A, 2) moderate cycling at 60% V˙O2peak C, and 3) easy cycling at 60% V˙O2peak A. Cytokine, adrenaline, and flow cytometric analysis of monocyte subsets were performed before and up to 4 h postexercise.
RESULTSPlasma IL-6 increased from resting concentrations in all trials; however, postexercise concentrations were higher for arm exercise (1.73 ± 1.04 pg·mL) and moderate cycling (1.73 ± 0.95 pg·mL) compared with easy cycling (0.87 ± 0.41 pg·mL; P < 0.04). Similarly, the plasma IL-1ra concentration in the recovery period was higher for arm exercise (325 ± 139 pg·mL) and moderate cycling (316 ± 128 pg·mL) when compared with easy cycling (245 ± 77 pg·mL, P < 0.04). Arm exercise and moderate cycling induced larger increases in monocyte numbers and larger increases of the classical monocyte subset in the recovery period than easy cycling (P < 0.05). The postexercise adrenaline concentration was lowest for easy cycling (P = 0.04).
CONCLUSIONSArm exercise and cycling at the same relative exercise intensity induces a comparable acute inflammatory response; however, cycling at the same absolute oxygen uptake as arm exercise results in a blunted cytokine, monocyte, and adrenaline response. Relative exercise intensity appears to be more important to the acute inflammatory response than modality, which is of major relevance for populations restricted to upper body exercise.