Dosimetry of blood irradiation with radiochromic film

• Published in: Transfusion medicine (Oxford, England) Vol. 9; no. 3; pp. 205 - 208
• Main Authors: Butson, M J, Yu, P K, Cheung, T, Carolan, M G, Quach, K Y, Arnold, A, Metcalfe, P E
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01-09-1999
• Subjects: Blood - radiation effects; blood products; dosimetry; Gafchromic; Graft vs Host Disease - prevention & control; graft vs. host disease; Humans; Radiation Dosage; radiochromic film; Transfusion Reaction; X-Ray Film
• ISSN: 0958-7578; 1365-3148
• DOI: 10.1046/j.1365-3148.1999.00200.x

It has been shown that radiochromic film is an ideal dosimeter for assessment and verification of delivered dose to irradiated blood products. Using a parallel opposing two‐field technique on a medical linear accelerator, blood is irradiated to diminish the risk of transfusion‐associated graft vs. host disease (TA‐GVHD). The blood products are irradiated in a Perspex blood box to an applied dose of 29.5–31.7 Gy. Verification of applied dose has been performed with thimble ionization chambers and radiochromic film. Radiochromic film results have matched absorbed dose measurements from ionization chambers at all sites within the ‘active’ treatment volume within ± 6% for a 95% confidence limit. Using a sample of 100 in‐vitro measurements, radiochromic film has measured the average applied dose to blood products to be 30.95 ± 2.6 Gy for two standard deviations. Like currently available ‘irradiated’ film labels, the radiochromic film also serves as a visible reminder that the blood products have been irradiated.