Effects of Ni2+ Ions on Cell Viability and NO Production of Murine Peritoneal Exudate Cells (Macrophages) with and without Lipopolysaccharide Stimulation

The purpose of this study was to clarify the cytotoxicity of Ni2+ ions against murine peritoneal exudate cells (PEC) (macrophages). First, we examined the cell viability of PEC with and without lipopolysaccharide (LPS) stimulation in culture media containing Ni2+ ions up to 1000μmol/L. Results showe...

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Bibliographic Details
Published in:	Dental Materials Journal Vol. 24; no. 3; pp. 304 - 310
Main Authors:	TAIRA, Masayuki, SASAKI, Minoru, YAMAURA-TANAKA, Chiharu, SAITOH, Setsuo, KIMURA, Shigenobu, ARAKI, Yoshima
Format:	Journal Article
Language:	English
Published:	Japan The Japanese Society for Dental Materials and Devices 01-09-2005
Subjects:	Actins - analysis Animals Cell Survival - drug effects Cells, Cultured Dose-Response Relationship, Drug Free Radical Scavengers - metabolism Interleukin-1 - analysis Interleukin-6 - analysis Lipopolysaccharides - administration & dosage Lipopolysaccharides - toxicity LPS Macrophages, Peritoneal - drug effects Mice Nickel - administration & dosage Nickel - toxicity Nickel ions Nitric Oxide - analysis Nitric Oxide - biosynthesis Nitric Oxide Synthase - analysis Nitric Oxide Synthase - drug effects Peritoneal exudate cells Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - drug effects
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