Challenges and opportunities for SERS in the infrared: materials and methods
In the wake of a global, heightened interest towards biomarker and disease detection prompted by the SARS-CoV-2 pandemic, surface enhanced Raman spectroscopy (SERS) positions itself again at the forefront of biosensing innovation. But is it ready to move from the laboratory to the clinic? This revie...
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| Published in: | Nanoscale advances Vol. 5; no. 8; pp. 2132 - 2166 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
RSC
11-04-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | In the wake of a global, heightened interest towards biomarker and disease detection prompted by the SARS-CoV-2 pandemic, surface enhanced Raman spectroscopy (SERS) positions itself again at the forefront of biosensing innovation. But is it ready to move from the laboratory to the clinic? This review presents the challenges associated with the application of SERS to the biomedical field, and thus, to the use of excitation sources in the near infrared, where
biological windows
allow for cell and through-tissue measurements. Two main tackling strategies will be discussed: (1) acting on the design of the enhancing substrate, which includes manipulation of nanoparticle shape, material, and supramolecular architecture, and (2) acting on the spectral collection set-up. A final perspective highlights the upcoming scientific and technological bets that need to be won in order for SERS to stably transition from benchtop to bedside.
NIR-SERS and the concomitant tailoring of the detection setup, as well as the tuning of shape, material, and architecture of the enhancing substrates, allow for bioanalytical studies, including cell and through-tissue measurements. |
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| Bibliography: | Chiara Deriu obtained her PhD in Chemistry from Florida International University (FIU), Miami, USA, in 2020, where she worked on tailoring the stabilization of nanomaterials for the detection of drugs by SERS. Following, she received a postdoctoral appointment at FIU to work on the computational modeling of adsorbates on bimetallic clusters. She then joined Politecnico di Torino (Italy) in September 2021, where she is an ERC-funded postdoctoral researcher. Her scientific interests lie at the intersection of physical chemistry and the analytical sciences, with particular attention to nanoscale surface chemistry and its effects on both nanofabrication and SERS analytical performance. Shaila Thakur obtained her PhD in Chemical Engineering from Indian Institute of Technology (IIT) Kharagpur, India in 2017. She worked as a postdoctoral scholar at National Center for Biological Sciences (NCBS) Bangalore (India) from 2020-2021. She joined Politecnico di Torino (Italy) as a postdoctoral fellow in 2022. She currently works on an ERC-funded project based on the utilization of plasmonic nanostructures for probing prostate cancer biomarkers. Her research interests include nanomaterial synthesis, biosensing, and interaction of nanomaterials with cells, DNA/RNA and proteins. Olimpia Tammaro is a postdoctoral researcher at the Department of Applied Sciences and Technologies at the Politecnico di Torino (Italy). She received an MSc in Materials Engineering from University of Naples "Federico II" (Italy) in 2016. She obtained her PhD in the group of Prof. P. A. Netti at IIT - CABHC (Italy) in 2020. The topic of her doctoral thesis was the development through a microfluidic platform of multi-modal probes. She then carried out postdoctoral research at the Politecnico di Torino (Italy) in the field of chemistry for technologies, with a focus on the synthesis of functional materials. Laura Fabris received her B.S./M.S. degree in Chemistry in 2001 from the University of Padova, where she was awarded a PhD in 2006. She was then a postdoc at the University of California Santa Barbara. In 2009 she moved to Rutgers University in the Department of Materials Science and Engineering where she remained first as Assistant then as Associate Professor. Upon receiving an ERC Consolidator Grant, she moved to Politecnico di Torino (Italy) in the Department of Applied Science and Technology where she is a Full Professor. Her research combines fundamental notions of nanomaterials chemistry and spectroscopy for the development of new technologies addressing important challenges in medicine, biology, and energy. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 2516-0230 2516-0230 |
| DOI: | 10.1039/d2na00930g |