Identification of a novel oligosaccharide backbone structure with a galactose residue monosubstituted at C-6 in human foetal gastrointestinal mucins

An oligosaccharide purified from a major penta- to hexa-saccharide fraction of human meconium glycoproteins has been shown by m.s. and n.m.r. analysis to have a novel backbone structure containing an internal galactose residue monosubstituted at C-6 by N-acetylglucosamine: (Formula: see text). This...

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Bibliographic Details
Published in:	Biochemical journal Vol. 256; no. 2; pp. 397 - 401
Main Authors:	Hounsell, E F, Lawson, A M, Feeney, J, Cashmore, G C, Kane, D P, Stoll, M, Feizi, T
Format:	Journal Article
Language:	English
Published:	England 01-12-1988
Subjects:	Carbohydrate Conformation Carbohydrate Sequence galactose Humans Infant, Newborn Magnetic Resonance Spectroscopy Mass Spectrometry Meconium - analysis mucins Mucins - analysis oligosaccharides Oligosaccharides - analysis
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Summary:	An oligosaccharide purified from a major penta- to hexa-saccharide fraction of human meconium glycoproteins has been shown by m.s. and n.m.r. analysis to have a novel backbone structure containing an internal galactose residue monosubstituted at C-6 by N-acetylglucosamine: (Formula: see text). This oligosaccharide may represent a biosynthetic product of a previously unrecognized N-acetylglucosaminyltransferase catalysing formation of a linear GlcNAc beta 1-6Gal sequence.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2560397