Protective effect of diltiazem, a L-type calcium channel antagonist, on bisphenol A-enhanced hydroxyl radical generation by 1-methyl-4-phenylpyridinium ion in rat striatum

• Published in: Neuroscience letters Vol. 334; no. 3; pp. 211 - 213
• Main Authors: OBATA, Toshio, KINEMUCHI, Hiroyasu, AOMINE, Masahiro
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier 16-12-2002
• Subjects: 1-Methyl-4-phenylpyridinium - toxicity; Animals; Benzhydryl Compounds; Biological and medical sciences; Calcium Channel Blockers - pharmacology; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Diltiazem - pharmacology; Drug Interactions; Free Radical Scavengers - pharmacology; Hydroxyl Radical - metabolism; Male; Medical sciences; Microdialysis; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Phenols - pharmacology; Rats; Rats, Wistar; Time Factors; Parkinson's disease; Rat; Central nervous system; Calcium antagonist; Parkinson disease; Ionic channel; Free radical; 1-Methyl-4-phenylpyridinium ion; Degenerative disease; Hydroxyl radical; Nervous system diseases; Rodentia; Basal ganglion; Corpus striatum; Neuroprotective agent; Diltiazem; Cerebral disorder; Bisphenol A; Vertebrata; Experimental disease; Mammalia; Animal; Central nervous system disease; Hydroxyl; Brain (vertebrata); Extrapyramidal syndrome
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/s0304-3940(02)01110-2

The present study examined whether bisphenol A enhanced 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in rat striatum using microdialysis technique. These elevations were detected by increases in non-enzymatic formation of 2,3-dihydroxybenzoic acid levels. Bisphenol A significantly enhanced MPP+-induced.OH generation. Further, the effect of diltiazem, a L-type Ca2+ channel antagonist, on bisphenol A (10 microM) and MPP+ (5 mM)-induced.OH generation were studied. Ddiltiazem (100 microM) significantly suppressed bisphenol A and MPP+-induced.OH generation. The results indicate bisphenol A augmented *OH generation, and diltiazem may have preventive effect on bisphenol A and MPP+-induced.OH generation.