Organocatalysed asymmetric Mannich reactions

Organocatalysed asymmetric Mannich reactions

The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutoria...

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Bibliographic Details
Published in:Chemical Society reviews Vol. 37; no. 1; p. 29
Main Authors: Verkade, Jorge M M, van Hemert, Lieke J C, Quaedflieg, Peter J L M, Rutjes, Floris P J T
Format: Journal Article
Language:English
Published: England 01-01-2008
Subjects:
Acetates - chemistry
Acids - chemistry
Alcohols - chemical synthesis
Alcohols - chemistry
Aldehydes - chemical synthesis
Aldehydes - chemistry
Amines - chemistry
Catalysis
Esters - chemistry
Imines - chemistry
Ketones - chemical synthesis
Ketones - chemistry
Stereoisomerism
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Summary:The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.
ISSN:0306-0012
DOI:10.1039/b713885g