Superwarfarin ingestion and detection

Because of the emergence of warfarin resistance, new potent long-acting anticoagulants are now readily available in several over-the-counter rodenticide products. The availability of these "superwarfarin" compounds has led to accidental and purposeful human ingestions, one of which has res...

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Bibliographic Details
Published in:	American journal of hematology Vol. 36; no. 1; p. 50
Main Authors:	Routh, C R, Triplett, D A, Murphy, M J, Felice, L J, Sadowski, J A, Bovill, E G
Format:	Journal Article
Language:	English
Published:	United States 01-01-1991
Subjects:	4-Hydroxycoumarins - blood 4-Hydroxycoumarins - metabolism Adult Female Humans Kidney - metabolism Liver - metabolism Osmolar Concentration Rodenticides - poisoning Substance-Related Disorders - diagnosis Vitamin K - blood Warfarin
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Summary:	Because of the emergence of warfarin resistance, new potent long-acting anticoagulants are now readily available in several over-the-counter rodenticide products. The availability of these "superwarfarin" compounds has led to accidental and purposeful human ingestions, one of which has resulted in a death. We summarize the prior case reports and report a second death. In addition, we report the availability of an assay to detect the presence of brodifacoum (a superwarfarin compound) in human plasma and tissues.
ISSN:	0361-8609
DOI:	10.1002/ajh.2830360111