Caloric Restriction in mTORC1 Control of Intestinal Homeostasis

Caloric Restriction in mTORC1 Control of Intestinal Homeostasis

Reducing caloric intake, while maintaining adequate nutrition, promotes longevity in diverse organisms, possibly by preserving stem and progenitor cell function. Yilmaz and colleagues (2012) now show that caloric restriction alters intestinal stem cell proliferation and differentiation, and elucidat...

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Bibliographic Details
Published in:Cell metabolism Vol. 16; no. 1; pp. 6 - 8
Main Authors: Harris, Thurl E., Thorner, Michael O.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 03-07-2012
Online Access:Get full text
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Summary:Reducing caloric intake, while maintaining adequate nutrition, promotes longevity in diverse organisms, possibly by preserving stem and progenitor cell function. Yilmaz and colleagues (2012) now show that caloric restriction alters intestinal stem cell proliferation and differentiation, and elucidate a mechanism for how the mammalian stem cell niche responds to environmental inputs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2012.06.010