Regulation of phosphatidylglycerolphosphate synthase in aerobic yeast Kluyveromyces lactis
The KlPGS1 gene encoding phosphatidylglycerolphosphate synthase (PGPS) is essential for the viability and multiplication of Kluyveromyces lactis . Regulation of PGPS expression by factors affecting mitochondrial development (C source, growth phase) and general phospholipid biosynthesis was followed....
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Published in: | Folia microbiologica Vol. 53; no. 4; pp. 319 - 324 |
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Main Authors: | , , |
Format: | Journal Article |
Language: | English |
Published: |
Dordrecht
Springer Netherlands
01-07-2008
Springer Nature B.V |
Subjects: | |
Online Access: | Get full text |
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Summary: | The
KlPGS1
gene encoding phosphatidylglycerolphosphate synthase (PGPS) is essential for the viability and multiplication of
Kluyveromyces lactis
. Regulation of PGPS expression by factors affecting mitochondrial development (C source, growth phase) and general phospholipid biosynthesis was followed.
PGS1
mRNA levels were not altered as cells progressed from the exponential to the stationary phase of growth in glucose.
PGS1
mRNA abundance was nearly identical in cells growing in a medium with glucose or glycerol as the sole C source during the different growth phases. Regulation of
PGS1
expression by exogenous
myo
-inositol and choline was not mediated at the transcriptional level, the PGPS activity dropped to 70 % after
myo
-inositol addition. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0015-5632 1874-9356 |
DOI: | 10.1007/s12223-008-0050-x |