Regulation of phosphatidylglycerolphosphate synthase in aerobic yeast Kluyveromyces lactis

The KlPGS1 gene encoding phosphatidylglycerolphosphate synthase (PGPS) is essential for the viability and multiplication of Kluyveromyces lactis . Regulation of PGPS expression by factors affecting mitochondrial development (C source, growth phase) and general phospholipid biosynthesis was followed....

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Published in:Folia microbiologica Vol. 53; no. 4; pp. 319 - 324
Main Authors: Ticha, E, Polakovicova, V, Obernauerova, M
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-07-2008
Springer Nature B.V
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Summary:The KlPGS1 gene encoding phosphatidylglycerolphosphate synthase (PGPS) is essential for the viability and multiplication of Kluyveromyces lactis . Regulation of PGPS expression by factors affecting mitochondrial development (C source, growth phase) and general phospholipid biosynthesis was followed. PGS1 mRNA levels were not altered as cells progressed from the exponential to the stationary phase of growth in glucose. PGS1 mRNA abundance was nearly identical in cells growing in a medium with glucose or glycerol as the sole C source during the different growth phases. Regulation of PGS1 expression by exogenous myo -inositol and choline was not mediated at the transcriptional level, the PGPS activity dropped to 70 % after myo -inositol addition.
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ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-008-0050-x