ILC regulation of T cell responses in inflammatory diseases and cancer

• Published in: Seminars in immunology Vol. 41; p. 101284
• Main Authors: Warner, Kathrin, Ohashi, Pamela S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-02-2019
• Subjects: Animals; Cancer; Disease Susceptibility; Humans; Immunity, Innate; Immunomodulation; Inflammat; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Innate lymphoid cells; Lymphocyte Activation; Lymphocytes - immunology; Lymphocytes - metabolism; Neoplasms - etiology; Neoplasms - metabolism; Neoplasms - pathology; Ory diseases; T cells; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Tumor immunology; Innate lymphoid cells; T cells; Ory diseases; Tumor immunology; Cancer; Inflammat
• ISSN: 1044-5323; 1096-3618
• DOI: 10.1016/j.smim.2019.101284

•Overview of ILC-T cell interactions in inflammation.•Local tissue and tumor microenvironment shape regulatory ILC functions.•Potential role for ILCs in regulating anti-tumor T cell responses.
The tumor microenvironment is shaped by interactions between tumor cells, stroma, and immune cells. T cells are a critical component of the immunological anti-tumor response and most immunotherapeutic approaches in cancer aim to augment T cell responses. Recently, innate lymphoid cells (ILCs) have been added to the list of cell populations that influence T cell responses within the tumor microenvironment. ILCs were shown to modulate T cell functions through a variety of mechanisms. However, the impact of ILC and T cell interactions on disease outcome appears to be contextual as their phenotype and function is strongly influenced by the local tissue microenvironment. Here we focus on recent advances in understanding the mechanisms of ILCs in regulating T cell responses in inflammatory diseases and cancer.