Retrograde radioisotope myocardial perfusion patterns in dogs

• Published in: Circulation (New York, N.Y.) Vol. 50; no. 1; pp. 159 - 166
• Main Authors: Cibulski, A A, Markov, A, Lehan, P H, Galyean, 3rd, J R, Smith, R O, Flowers, Jr, W M, Hellems, H K
• Format: Journal Article
• Language: English
• Published: United States 01-07-1974
• Subjects: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Disease - diagnosis; Coronary Disease - physiopathology; Coronary Vessels; Dogs; Heart - physiopathology; Heart Rate; Heart Ventricles - physiopathology; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Krypton - administration & dosage; Methods; Myocardium - pathology; Perfusion; Potassium Isotopes; Radioisotopes - administration & dosage; Radionuclide Imaging; Veins
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.50.1.159

A retrograde coronary vein injection technique for concentrating radioisotope in ischemic myocardial regions was evaluated in dogs. Potassium-43 in saline solution was injected into the coronary veins during complete closure of the coronary sinus. In the presence of coronary inflow obstruction, the venous potassium-43 was distributed mainly to the low pressure vessels in ischemic heart regions; i.e., the ratio of potassium-43 in the occluded-to-unoccluded areas ranged from 2:1 to 3:1 thirty seconds after retrograde injections. Krypton-85 in saline solution was injected under pressure into the coronary veins during partial closure of the coronary sinus. In the presence of inflow obstruction, the ratio of krypton-85 in the occluded- to-unoccluded areas ranged from 4:1 to 6:1 sixty seconds after retrograde injections; larger ratios may be expected after rapid washout of gas from the normally perfused region is nearly complete. Myocardial potassium-43 imaging techniques were applied to locate and measure the size of the ischemic heart region as a radioisotopic hot spot. Detection of hypoperfused areas of extremely small size may be accomplished by this technique.