Micellar carrier based on methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) block copolymers bearing ketone groups on the polyester block for doxorubicin delivery

• Published in: Journal of materials science. Materials in medicine Vol. 21; no. 2; pp. 567 - 574
• Main Authors: Yueying, He, Yan, Zhang, Chunhua, Gu, Weifeng, Dai, Meidong, Lang
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-02-2010; Springer; Springer Nature B.V
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Biological and medical sciences; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Ceramics; Chemical synthesis; Chemistry and Materials Science; Chemotherapy; Composites; Delayed-Action Preparations - chemistry; Diffusion; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Drug Compounding - methods; Glass; Ketones - chemistry; Materials Science; Materials Testing; Medical research; Medical sciences; Micelles; Natural Materials; Polyesters - chemistry; Polyethylene Glycols - chemistry; Polymer Sciences; Polymers; Regenerative Medicine/Tissue Engineering; Surfaces and Interfaces; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Thin Films; Critical Micelle Concentration; Encapsulation Efficiency; Polymeric Micelle; Block Copolymer; Dynamic Light Scattering; DNA topoisomerase (ATP-hydrolysing); Enzyme; Controlled release form; Ester polymer; Enzyme inhibitor; Micelle; Drug carrier; Topoisomerase II inhibitor; Ketone; Doxorubicin; Lactone polymer; Ethylene oxide polymer; Antibiotic; Isomerases; Cyclic ether polymer; Aliphatic polymer; Anthracyclins; Chemical synthesis; Polycaprolactone; Block copolymer; Biomedical engineering
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-009-3887-x

Block copolymers of Methoxy poly(ethylene glycol)-block-poly(
ε
-caprolactone) bearing ketone groups (MPEG-
b
-P(CL-
co
-OPD)) are synthesized and evaluated for its potential to form micelles containing doxorubicin (DOX), a representative anticancer drug, by using an in vitro method based on membrane dialysis to emulate drug release in vivo. The
1
H NMR spectra of the prepared block copolymers in D
2
O solution exhibit peaks due to the P(OPD-
co
-CL) in decreased intensity, indicates that the polymers form micelle particles containing the hydrophilic segments in their external parts. The CMC of the copolymer decrease with an increase in the content of ketone groups in the hydrophobic chain. Drug-free and drug-loaded solutions of structurally related copolymers indicate the polymeric aggregation into micellar-type constructs. The size of the drug-loaded micelles is found to be larger than corresponding drug-free micelles. The release rate of MPEG-
b
-PCL micelles is faster than MPEG-
b
-P(OPD-
co
-CL) micelles in pH 7.4 buffered solution and they have a similar release rate in pH 5.0 buffered solution. This study, therefore, confirms the potential of a novel functional block copolymers, Methoxy poly(ethylene glycol)-block-poly(
ε
-caprolactone) bearing ketone Groups, for the formation of polymeric micelles for drug delivery.