Hepatic Mucinous Cystic Neoplasm Versus Simple Biliary Cyst: Assessment of Distinguishing Imaging Features Using CT and MRI

• Published in: American journal of roentgenology (1976) Vol. 216; no. 2; pp. 403 - 411
• Main Authors: Boyum, James H, Sheedy, Shannon P, Graham, Rondell P, Olson, Joshua T, Babcock, Andrew T, Bolan, Candice W, Menias, Christine O, Venkatesh, Sudhakar K
• Format: Journal Article
• Language: English
• Published: United States 01-02-2021
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Bile Duct Diseases - diagnostic imaging; Bile Duct Diseases - surgery; Cysts - diagnostic imaging; Diagnosis, Differential; Female; Humans; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - surgery; Magnetic Resonance Imaging; Male; Middle Aged; Predictive Value of Tests; Retrospective Studies; Tomography, X-Ray Computed; Young Adult; mucinous cystic neoplasm; hepatic; septations; simple biliary cyst
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/ajr.20.22768

The purpose of our study was to identify the imaging features that differentiate a hepatic mucinous cystic neoplasm (MCN) from a simple biliary cyst.
Surgically resected hepatic MCNs and simple biliary cysts over a 20-year period (October 29, 1997-January 23, 2018) with preoperative CT, MRI, or both were retrospectively identified. Included cases underwent histopathologic confirmation of diagnosis based on the 2010 World Health Organization criteria and blinded imaging review. Various imaging features, including cyst shape and septal enhancement, were assessed for performance. For septate cysts, the relationship of the septation to the cyst wall-that is, arising from the wall without an indentation versus arising from an external macrolobulation-was recorded. Statistical analysis was performed for the imaging features with the chi-square test.
The study group comprised 22 hepatic MCNs and 56 simple biliary cysts. A unilocular hepatic cystic lesion was highly predictive of a simple biliary cyst (positive predictive value = 95.2%). The imaging feature of septations arising only from macro-lobulations was 100% specific for a simple biliary cyst on CT (
= 0.001). The presence of septations arising from the cyst wall without indentation was 100% sensitive for hepatic MCN but was only 56.3% specific on CT. Septal enhancement reached 100% sensitivity for hepatic MCN on MRI (
= 0.018).
The presence of septations, relationship of the septations to the cyst wall, and septal enhancement were sensitive imaging features in the detection of hepatic MCN. The imaging feature of septations arising only from macrolobulations in the cyst wall was specific for simple biliary cysts on CT and helped differentiate simple biliary cysts from hepatic MCNs.