Bone-adiposity cross-talk: implications for pediatric obesity A narrative review of literature

• Published in: Journal of bone and mineral metabolism Vol. 33; no. 6; pp. 592 - 602
• Main Authors: Chaplais, Elodie, Thivel, David, Greene, David, Dutheil, Frederic, Duche, Pascale, Naughton, Geraldine, Courteix, Daniel
• Format: Journal Article Book Review
• Language: English
• Published: Tokyo Springer Japan 01-11-2015; Springer Nature B.V; Springer Verlag
• Subjects: Adipocytes - pathology; Adiposity; Adolescent; Endocrinology and metabolism; Human health and pathology; Humans; Life Sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Organ Size; Orthopedics; Pediatric Obesity - pathology; Pediatrics; Review Article; Rhumatology and musculoskeletal system; Weight Loss; Obesity; Adipocyte; Adolescents; Osteocyte
• ISSN: 0914-8779; 1435-5604
• DOI: 10.1007/s00774-015-0654-6

The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex interactions between adipocyte and osteocyte activities may contribute to the mechanistic understanding of the body’s responses to weight loss during adolescence. This knowledge could also reveal any side effects encountered with these interventions. Currently, the concept of bone-adiposity crosstalk has not been fully elucidated, and the mechanisms remain controversial. Understanding the local interactions between the released products by fat tissue and hormones produced in bone tissue requires further investigations.