The mitochondrial antioxidant defence system and its response to oxidative stress

• Published in: Proteomics (Weinheim) Vol. 1; no. 9; pp. 1105 - 1110
• Main Authors: Rabilloud, Thierry, Heller, Manfred, Rigobello, Maria-Pia, Bindoli, Alberto, Aebersold, Ruedi, Lunardi, Joël
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag GmbH 01-09-2001; WILEY‐VCH Verlag GmbH
• Subjects: Animals; Antioxidants - metabolism; Antitioxidant systems; Humans; Jurkat Cells; Manganese superoxide dismutase; Mitochondria; Mitochondria - enzymology; Mitochondria - metabolism; Oxidative Stress; Peroxiredoxin III; Rats; Thioredoxin-Disulfide Reductase - chemistry; Thioredoxin-Disulfide Reductase - metabolism
• ISSN: 1615-9853; 1615-9861
• DOI: 10.1002/1615-9861(200109)1:9<1105::AID-PROT1105>3.0.CO;2-M

The antioxidant systems of mitochondria are not well known. Using a proteomics‐based approach, we defined these mitochondrial antioxidant systems and analyzed their response to oxidative stress. It appears that the major mitochondrial antioxidant system is made of manganese superoxide dismutase on the one hand, and of peroxiredoxin III, mitochondrial thioredoxin and mitochondrial thioredoxin reductase on the other hand. With the exception of thioredoxin reductase, all these proteins are induced by oxidative stress. In addition, a change in the peroxiredoxin III pattern can also be observed.