Long-term results of endoscopic management of pancreas divisum with recurrent acute pancreatitis

• Published in: Gastrointestinal endoscopy Vol. 55; no. 3; pp. 376 - 381
• Main Authors: Heyries, Laurent, Barthet, Marc, Delvasto, Claude, Zamora, Christophe, Bernard, Jean-Paul, Sahel, José
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01-03-2002; Elsevier
• Subjects: Acute Disease; Adult; Aged; Biological and medical sciences; Cholangiopancreatography, Endoscopic Retrograde - adverse effects; Female; Humans; Length of Stay; Liver, biliary tract, pancreas, portal circulation, spleen; Male; Medical sciences; Middle Aged; Pancreas - abnormalities; Pancreatitis - etiology; Pancreatitis - prevention & control; Pancreatitis - therapy; Secondary Prevention; Sphincterotomy, Endoscopic; Stents; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Time Factors; Treatment Outcome; Human; Recurrence; Acute; Treatment efficiency; Pancreatitis; Instrumentation therapy; Instrumental dilatation; Long term; Stent; Association; Pancreas divisum; Surgery; Digestive diseases; Sphincterotomy; Endoscopy; Technique; Pancreatic disease
• ISSN: 0016-5107; 1097-6779
• DOI: 10.1067/mge.2002.121602

Background: The long-term efficacy of endoscopic treatment in pancreas divisum is controversial. This study evaluated the long-term results of dorsal duct stent insertion and endoscopic sphincterotomy of the minor papilla in patients presenting with recurrent acute pancreatitis or chronic pain. Methods: Pancreas divisum was diagnosed in 175 patients between 1980 and 1998. Twenty-four patients seen with recurrent acute pancreatitis without underlying chronic calcifying pancreatitis or significant alcohol consumption were included in this study with a follow-up of at least 24 months. Eight were treated by sphincterotomy of the minor papilla alone, and 16 underwent dorsal duct stent insertion for a median duration of 8 months. Results: The median duration of follow-up after endoscopic management was 39 months (range 24-105; interquartile range 40.5). All patients had recurrent acute pancreatitis before endoscopic treatment during a median period of 5 years. At the end of the follow-up there were only 2 recurrences of acute pancreatitis (p < 0.01). The number of patients with chronic pain before endoscopic treatment and at the end of follow-up decreased from 20 of 24 (83%) to 7 of 24 (29%) without reaching statistical significance. The 25% recurrence rate was estimated at 50 months by Kaplan-Meier analysis. Nine patients presented with a dilated dorsal duct before endoscopic treatment. After stent insertion, dorsal duct dilatation appeared in all 16 patients who underwent stent placement, and pancreatic duct stenosis developed in 3. Four patients (19%) required further treatment for pain recurrence or acute pancreatitis, with surgical procedures being performed in 2 cases. Complications occurred in 9 of 24 patients (38%), mainly acute pancreatitis or stenosis of the minor papilla. All complications except one were managed conservatively. Complications seemed to be less frequent after minor papilla sphincterotomy than after pancreatic stent insertion (25% vs. 44%). Conclusion: In patients with pancreas divisum, both dorsal duct stent insertion and minor papilla sphincterotomy decrease the rate of recurrent acute pancreatitis, whereas relief of chronic pain was less obvious. (Gastrointest Endosc 2002;55:376-81.)