EPR hyperthermia of S. cerevisiae using superparamagnetic Fe3O4 nanoparticles

• Published in: Journal of thermal biology Vol. 77; pp. 55 - 61
• Main Authors: Khmelinskii, I., Makarov, V.I.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-10-2018; Elsevier BV
• Subjects: Cancer; Cells; Electromagnetic fields; Heating; Hyperthermia; Iron oxides; Magnetic resonance imaging; Magnetite; Nanoparticles; Radio frequency; Saccharomyces cerevisiae; Studies; Yeast
• ISSN: 0306-4565; 1879-0992
• DOI: 10.1016/j.jtherbio.2018.08.004

Presently we communicate a newly developed method of resonant radiofrequency heating, applicable in hyperthermal therapy. This method uses electron paramagnetic resonance (EPR) to transform the electromagnetic field energy into heat. We report the growth dynamics of the S. cerevisiae yeast cells exposed to EPR heating with superparamagnetic magnetite (Fe3O4) nanoparticles, with only 4% of yeast cells surviving hyperthermia. Given that EPR functions independently of type of the biologic species exposed, and produces spatially localized heating in conjunction with MRI hardware, it may be used in hyperthermal therapy of cancer and other diseases.
•The method was tested on yeast at 1W cm−3 RF power level and 100 Gs magnetic field, with 96% of all cells destroyed.•This method may provide localized heating of a zone that has appropriate strength of magnetic field.
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