Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation

Highlights • Ageing dysregulates cholesterol metabolism via a number of mechanisms. • Changes to the gut microbiome may play a role in dysregulating cholesterol metabolism. • The Mediterranean diet may be used as a strategy to mitigate these changes. • Mathematical modelling can be used to investiga...

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Bibliographic Details
Published in:	Ageing research reviews Vol. 27; pp. 108 - 124
Main Authors:	Morgan, A.E, Mooney, K.M, Wilkinson, S.J, Pickles, N.A, Mc Auley, M.T
Format:	Journal Article
Language:	English
Published:	England 01-05-2016
Subjects:	Aging - metabolism Animals Atherosclerosis - metabolism Atherosclerosis - prevention & control Cholesterol - metabolism Diet Humans Internal Medicine Lipid Metabolism Models, Theoretical Neurology Oxidative Stress longevity ageing low density lipoprotein cholesterol (LDL-C) microbiome high density lipoprotein cholesterol (HDL-C) Cholesterol Low density lipoprotein cholesterol (LDL-C) Longevity High density lipoprotein cholesterol (HDL-C) Ageing Microbiome
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Summary:	Highlights • Ageing dysregulates cholesterol metabolism via a number of mechanisms. • Changes to the gut microbiome may play a role in dysregulating cholesterol metabolism. • The Mediterranean diet may be used as a strategy to mitigate these changes. • Mathematical modelling can be used to investigate cholesterol metabolism and ageing.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2016.03.008