COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs

Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as det...

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 56; no. 63; p. 8972
Main Authors:	Navascuez, Marcos, Dupin, Damien, Grande, Hans-Jürgen, Gómez-Vallejo, Vanessa, Loinaz, Iraida, Cossío, Unai, Llop, Jordi
Format:	Journal Article
Language:	English
Published:	England 14-08-2020
Subjects:	Animals Cobalt - chemistry Contrast Media - chemistry Emulsions - chemistry Estradiol - chemistry Fatty Acids, Omega-3 - chemistry Fatty Acids, Omega-3 - metabolism Lung - diagnostic imaging Lung - metabolism Nanostructures - chemistry Oils - chemistry Positron Emission Tomography Computed Tomography Solubility Water - chemistry
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Summary:	Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as determined by in vivo positron emission tomography imaging.
ISSN:	1364-548X
DOI:	10.1039/d0cc00918k