Neurologic Complications in Treated HIV-1 Infection

Effective combination antiretroviral therapy has transformed HIV infection into a chronic disease, with HIV-infected individuals living longer and reaching older age. Neurological disease remains common in treated HIV, however, due in part to ongoing inflammation and immune activation that persist i...

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Bibliographic Details
Published in:	Current neurology and neuroscience reports Vol. 16; no. 7; p. 62
Main Authors:	Bhatia, Nisha S., Chow, Felicia C.
Format:	Journal Article Book Review
Language:	English
Published:	New York Springer US 01-07-2016 Springer Nature B.V
Subjects:	HIV Infections - complications HIV Infections - drug therapy HIV-1 - drug effects HIV-1 - pathogenicity Humans Infection (J Halperin Medicine Medicine & Public Health Nervous System Diseases - etiology Neurology Neurosciences Section Editor Topical Collection on Infection HIV infection Neurological complications Viral suppression
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Summary:	Effective combination antiretroviral therapy has transformed HIV infection into a chronic disease, with HIV-infected individuals living longer and reaching older age. Neurological disease remains common in treated HIV, however, due in part to ongoing inflammation and immune activation that persist in chronic infection. In this review, we highlight recent developments in our understanding of several clinically relevant neurologic complications that can occur in HIV infection despite treatment, including HIV-associated neurocognitive disorders, symptomatic CSF escape, cerebrovascular disease, and peripheral neuropathy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1528-4042 1534-6293
DOI:	10.1007/s11910-016-0666-1