Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

• Published in: Journal of the Serbian Chemical Society Vol. 83; no. 3; pp. 271 - 284
• Main Authors: Mihalache, Mădălina, Negreanu-Pirjol, Ticuţa, Florea Dumitraşcu, Drăghici, Constantin, Călinescu, Mirela
• Format: Journal Article
• Language: English
• Published: Belgrade Journal of the Serbian Chemical Society 01-01-2018; Serbian Chemical Society
• Subjects: Antimicrobial agents; Antioxidants; Bacteria; biguanide metal complexes; Biological activity; Chlorhexidine; Complex compounds; Coordination compounds; Nickel compounds; Palladium; transition metal complexes
• ISSN: 0352-5139; 1820-7421
• DOI: 10.2298/JSC170911119M

Six new coordination compounds of Ni(II), Pd(II) and Cr(III) with chlor­hexidine, 1,1′-hexamethylenebis[5-(4-chlorophenyl)biguanide], were pre­pared, characterized and examined for their potential as antimicrobial agents, as well as for their antioxidant activity. The metal complexes correspond to the formulas: [Ni(CHX)]Cl2·2H2O, [Ni(CHX)]Br2·2H2O, [Ni(CHX)](CH3COO)2·C2H5OH, [Pd(CHX)][PdCl4]·2H2O, [Pd(CHX)](CH3COO)2 and [Cr(CHX)Cl2](CH3COO), where CHX = chlorhexidine. Investigations on the in vitro antimicrobial act­ivity of the complexes indicated that all have high activity against the tested bacteria, but are less active against fungi. Among the six complexes, those of Pd(II) showed the highest antibacterial activity, [Pd(CHX)][PdCl4]·2H2O being more active against Gram-positive and Gram-negative bacteria than chlorhex­idine diacetate. The antioxidant activity of the metal complexes was inves­t­igated by photochemiluminescence and the results showed that the palla­dium(II) complexes have high antioxidant activities.