Applying Physiological and Biochemical Concepts to Optimize Biological Drug Development

Posology—the science of dose and regimen—is a critical part of drug development. It is concerned with ensuring that patients experience significant clinical benefit without intolerable adverse effects. It has become apparent, in the case of certain biologics, that one can directly quantitate occupan...

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Bibliographic Details
Published in:	Clinical pharmacology and therapeutics Vol. 87; no. 4; pp. 492 - 496
Main Author:	Lowe, PJ
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-04-2010
Subjects:	Biological and medical sciences Biological Products - administration & dosage Biological Products - adverse effects Biological Products - pharmacology Clinical Trials as Topic - methods Computer Simulation Dose-Response Relationship, Drug Drug Design Humans Medical sciences Models, Biological Pharmacology. Drug treatments Concept Human Drug Biochemistry Research and development
Online Access:	Get full text
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Summary:	Posology—the science of dose and regimen—is a critical part of drug development. It is concerned with ensuring that patients experience significant clinical benefit without intolerable adverse effects. It has become apparent, in the case of certain biologics, that one can directly quantitate occupancy or target capture and relate these to clinical responses. With mathematical models that integrate binding concepts with clinical effects, potential posologies can be quickly explored through simulation, thereby liberating research teams from the traditional constraints and simultaneously stimulating innovation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2009.302