CD7/CD19 double-positive T-cell acute lymphoblastic leukemia

• Published in: International journal of hematology Vol. 83; no. 4; pp. 324 - 327
• Main Authors: FUJISAWA, Shinya, TANIOKA, Fumihiko, MATSUOKA, Toshihiko, OZAWA, Takachika, NAITO, Kensuke, KOBAYASHI, Masahide
• Format: Journal Article
• Language: English
• Published: Tokyo Springer 01-05-2006; Springer Nature B.V
• Subjects: Antigens, CD19; Antigens, CD7; Biological and medical sciences; Disease-Free Survival; Head and Neck Neoplasms - diagnostic imaging; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - pathology; Hematologic and hematopoietic diseases; Humans; Leukemia-Lymphoma, Adult T-Cell - diagnostic imaging; Leukemia-Lymphoma, Adult T-Cell - drug therapy; Leukemia-Lymphoma, Adult T-Cell - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Pleural Effusion, Malignant - diagnostic imaging; Pleural Effusion, Malignant - drug therapy; Pleural Effusion, Malignant - pathology; Pneumology; Radiography; Remission Induction; Respiratory system : syndromes and miscellaneous diseases; Lymph node; Hematology; Respiratory disease; Acute; Pleural effusion; Malignant hemopathy; T-cell acute lymphoblastic leukemia; Lymph node swelling; Precusor T lymphoblastic leukemia; Lymphoproliferative syndrome; CD19; Pleurisy; CD7; Pleural disease; Acute lymphocytic leukemia
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1532/IJH97.05130

We report a rare case of T-cell acute lymphoblastic leukemia (T-ALL) with an aberrant phenotype. A 52-year-old man was admitted to our hospital because of lymph node (LN) swelling in the bilateral neck. A computed tomographic scan showed LN swelling in the mediastinum and a right pleural effusion. The tumor cells in the neck LN showed positivity for cytoplasmic CD3, CD7, CD19, and CD79a, whereas the tumor cells in the bone marrow (BM) showed positivity for CD10 and CD13 in addition to the former 4 antigens. The chromosomes in the BM were normal. Neither T-cell receptor gamma nor immunoglobulin heavy chain rearrangement was detected in the neck LN. We diagnosed this case as T-ALL with an aberrant phenotype and started the standard chemotherapy for ALL. The response was so effective that complete remission (CR) was easily attained. The patient is now under maintenance therapy in the first CR without hematopoietic cell transplantation.