Bone Turnover Markers

• Published in: Proceedings of Singapore healthcare Vol. 19; no. 3; pp. 273 - 275
• Main Authors: Yap, Clementine YF, Aw, Tar Choon
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-09-2010; SAGE Publishing
• Subjects: Procollagen Type 1 N-terminal Propeptide (P1NP); Bone Turnover Markers (BTM); Osteocalcin (OC); Bone Mineral Density (BMD); C-terminal cross-linked telopeptide of bone collagen (CTX)
• ISSN: 2010-1058; 2059-2329
• DOI: 10.1177/201010581001900315

Bone turnover markers (BTM) provide useful data to titrate the optimal dosing regimes for patients within 3–6 months as compared to 1–2 years using bone mineral density (BMD). Serum obtained under standardised conditions (fasting, early morning) should be tested using a precise automated immunoassay for a panel of bone markers that includes a resorption marker — C-terminal cross-linked telopeptide of bone collagen (CTX) — and formation markers — Procollagen Type 1 N-terminal Propeptide (P1NP) and Osteocalcin (OC).