Tropane alkaloids from the stem bark of Erythroxylum bezerrae

• Published in: Phytochemistry (Oxford) Vol. 178; p. 112458
• Main Authors: Brito, Luana San de O., Pinto, Francisco das Chagas L., de Filho, Manoel Odorico M., Rocha, Danilo D., Mendoza, Maria Fernanda M., Ayala, Alejandro Pedro, Bezerra, Beatriz Pinheiro, Loiola, Maria Iracema B., Canuto, Kirley M., Silveira, Edilberto R., Pessoa, Otilia Deusdenia L.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-10-2020
• Subjects: Cytotoxic activity; Erythroxylaceae; Erythroxylum bezerrae Plowman; Tropane alkaloids; Erythroxylaceae; Erythroxylum bezerrae Plowman; Tropane alkaloids; Cytotoxic activity
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2020.112458

Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively.
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•Eight tropane alkaloids, six undescribed, were isolated from Erythroxylum bezerrae.•The structures of three alkaloids were established by X-ray diffraction analysis.•One alkaloid was moderately active against HCT-116 and NCI-H460 cancer cell lines.