Study of bipathic effect of haloperidol

Parallel treatment with haloperidol and ultralow-dose haloperidol significantly increased the psychotropic neuroleptic effect of traditional doses of the drug under conditions of preliminary of simultaneous administration, which attests to a bipathic effect of this preparation. Combination of ultral...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 145; no. 5; pp. 620 - 622
Main Authors:	Voronina, T. A., Belopolskaya, M. V., Kheyfets, I. A., Dugina, J. L., Sergeeva, S. A., Epstein, O. I.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-05-2008 Springer Nature B.V
Subjects:	Animals Antipsychotic Agents - administration & dosage Antipsychotic Agents - adverse effects Apomorphine - administration & dosage Biomedical and Life Sciences Biomedicine Catalepsy - chemically induced Catalepsy - prevention & control Cell Biology Dopamine Agonists - administration & dosage Dose-Response Relationship, Drug Haloperidol Haloperidol - administration & dosage Haloperidol - adverse effects Internal Medicine Laboratory Medicine Male Mice Mice, Inbred C57BL Muscarinic Antagonists - administration & dosage Pathology Stereotyped Behavior - drug effects Trihexyphenidyl - administration & dosage haloperidol catalepsy bipathy psychotropic activity ultralow doses
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Summary:	Parallel treatment with haloperidol and ultralow-dose haloperidol significantly increased the psychotropic neuroleptic effect of traditional doses of the drug under conditions of preliminary of simultaneous administration, which attests to a bipathic effect of this preparation. Combination of ultralow and therapeutic doses of haloperidol significantly reducted its cataleptogenic side effect.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-008-0156-9