Efficacy of 1.23% acidulated phosphate fluoride gel on non-cavitated enamel lesions: a randomized clinical trial

• Published in: Brazilian oral research Vol. 35; p. e038
• Main Authors: Goldenfum, Gabriela Maltz, Silva, Natália Caldeira, Almeida, Ingrid Dos Anjos, Neves, Matheus, Silva, Berenice Barbachan E, Jardim, Juliana Jobim, Rodrigues, Jonas Almeida
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Pesquisa Odontológica - SBPqO 2021; Sociedade Brasileira de Pesquisa Odontológica
• Subjects: Acidulated Phosphate Fluoride; Cariostatic Agents - therapeutic use; Child; Dental Caries; Dental Caries - prevention & control; Dental Enamel; Dentistry; DENTISTRY, ORAL SURGERY & MEDICINE; Humans; Pediatric Dentistry; Tooth, Deciduous; Toothbrushing; Dental Caries; Pediatric Dentistry; Acidulated Phosphate Fluoride
• ISSN: 1806-8324; 1807-3107; 1807-3107
• DOI: 10.1590/1807-3107BOR-2021.VOL35.0038

A randomized controlled parallel clinical trial was conducted to evaluate the efficacy of the association of 1.23% topical professional acidulated phosphate fluoride (APF) gel with oral hygiene and dietary instructions on the arrest of active non-cavitated lesions in permanent, mixed, and temporary dentition in children between 3 and 12 years of age. Ninety-eight caries-active children were randomly divided into two groups: a fluoride gel group (n = 49) and a non-fluoridated gel group (n = 49). Each group received up to eight weekly applications of gel, weekly professional toothbrushing with oral hygiene instructions and dietary counselling. Caries lesions were assessed qualitatively through visual-tactile criteria performed in three stages: initial, intermediate, and final. Regression models were applied to identify risk indicators for caries control. Between-group comparison regarding the time taken to arrest the lesions was performed using Chi-squared and Fisher's exact tests. Seventeen children did not receive the allocated intervention, and one was lost to follow-up (n = 80). There was no difference between the control and placebo groups regarding the time to the arrest of the lesion (p >.05). The treatments showed similar results without significant statistical difference (p = 0.33; 95%CI: 0.32-1.48). No adverse effects were observed. It can be concluded that no additional effect of the association of 1.23% APF gel with oral hygiene using fluoride dentifrice and dietary instructions on the arrest of active non-cavitated lesions could be established. We can also confirm the importance of toothbrushing frequency and, consequently, the visible plaque reduction in the control of caries activity. RBR-37V5S3.