Drug Dosing in Patients With Impaired Renal Function

Renal function can affect disposition and response to drugs in a variety of ways. This review discusses the principles underlying such responses, with particular emphasis on how changes in disposition parameters affect dosing decisions. Clinical Pharmacology & Therapeutics (2009) 86 5, 483–489....

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Bibliographic Details
Published in:	Clinical pharmacology and therapeutics Vol. 86; no. 5; pp. 483 - 489
Main Author:	Brater, DC
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-11-2009
Subjects:	Biological and medical sciences Dose-Response Relationship, Drug Humans Kidney Function Tests Medical sciences Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacology. Drug treatments Renal Dialysis - methods Renal Insufficiency - physiopathology Renal Insufficiency - therapy Human Drug Patient Renal function Posology
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Summary:	Renal function can affect disposition and response to drugs in a variety of ways. This review discusses the principles underlying such responses, with particular emphasis on how changes in disposition parameters affect dosing decisions. Clinical Pharmacology & Therapeutics (2009) 86 5, 483–489. doi:10.1038/clpt.2009.135
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2009.135