Integrated Clinical Scale Manufacturing System for Cellular Products Derived by Magnetic Cell Separation, Centrifugation and Cell Culture

Manufacturing of cellular products for therapeutic purposes like stem cell or cancer therapy requires equipment with specific characteristics not always addressed by conventional technologies. A new integrated cell processing device is presented that can handle all current technical requirements for...

Full description

Saved in:
Bibliographic Details
Published in:Chemie ingenieur technik Vol. 85; no. 1-2; pp. 103 - 110
Main Authors: Apel, Michael, Brüning, Mareke, Granzin, Markus, Essl, Mike, Stuth, Juliane, Blaschke, Jessica, Spiegel, Iris, Müller, Sabine, Kabaha, Eiad, Fahrendorff, Elmar, Miltenyi, Stefan, Schmitz, Jürgen, Balshüsemann, Dirk, Huppert, Volker
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 01-02-2013
WILEY‐VCH Verlag
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Manufacturing of cellular products for therapeutic purposes like stem cell or cancer therapy requires equipment with specific characteristics not always addressed by conventional technologies. A new integrated cell processing device is presented that can handle all current technical requirements for manufacturing cellular products by automation of the complete process in a GMP‐compliant single‐use tubing set. Its capabilities are exemplified in the presented study by successful processing of adult stem cells, natural killer cells, and several cell lines. Multiple cell processing workflows can be automated in a functionally closed environment: from cell separation through cell culture to formulation of the final product. A new platform technology for cell processing is introduced that facilitates fully automated manufacturing of cellular products for clinical applications in a single‐use tubing set. This functionally closed disposable integrates multiple workflows like cell washing, labeling, separation and cultivation. Thereby, it may allow advancing innovative research into next generation cellular therapies for routine use.
Bibliography:German Federal Ministry of Education and Research - No. 0312138B
ark:/67375/WNG-PDHWM3Q6-Z
istex:A0832C93F8DF533CE6988D3768BBE4BC730DC38E
ArticleID:CITE201200175
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0009-286X
1522-2640
DOI:10.1002/cite.201200175