Vitamin D3 for the Treatment of Epilepsy: Basic Mechanisms, Animal Models, and Clinical Trials

Vitamin D3 for the Treatment of Epilepsy: Basic Mechanisms, Animal Models, and Clinical Trials

There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Vitamin D3 is actively under investigation as a potential intervention for epilepsy. Vitamin D3 is fat-soluble steroid, which shows pro...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in neurology Vol. 7; p. 218
Main Authors: Pendo, Kevin, DeGiorgio, Christopher M
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 08-12-2016
Subjects:
Neuroscience
epilepsy
cholecalciferol
animal models
clinical trials
SUDEP
vitamin D3
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Vitamin D3 is actively under investigation as a potential intervention for epilepsy. Vitamin D3 is fat-soluble steroid, which shows promise in animal models of epilepsy. Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy. Very little clinical data exist to support the treatment of human epilepsy with Vitamin D3, but positive findings from preliminary clinical trials warrant larger Phase I and II clinical trials in order to more rigorously determine the potential therapeutic value of Vitamin D3 as a treatment for human epilepsy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Jeremy Daniel Slater, University of Texas Medical School at Houston, USA
Specialty section: This article was submitted to Epilepsy, a section of the journal Frontiers in Neurology
Reviewed by: Patricia Braga, School of Medicine, Montevideo, Uruguay; Detlev Boison, Legacy Health, USA
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2016.00218