What do the terms resistance, tolerance, and resilience mean in the case of Ostrea edulis infected by the haplosporidian parasite Bonamia ostreae

• Published in: Journal of invertebrate pathology Vol. 182; p. 107579
• Main Authors: Holbrook, Zoë, Bean, Tim P., Lynch, Sharon A., Hauton, Chris
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2021
• Subjects: Bonamia ostreae; Definitions; Ostrea edulis; Resistance; Restoration; Tolerance; Resistance; Bonamia ostreae; Tolerance; Restoration; Ostrea edulis; Definitions
• ISSN: 0022-2011; 1096-0805
• DOI: 10.1016/j.jip.2021.107579

•Bonamiosis develops unpredictably in individuals and populations.•Identifying resistance and tolerance is difficult from cellular observations alone.•Resistant hosts actively restrict parasite proliferation.•Tolerance describes a host that is simply not affected by the parasite.•Resilience populations can be defined as those that recover from outbreaks.•Robust definitions are essential to progress the field of oyster restoration.
The decline of the European flat oyster Ostrea edulis represents a loss to European coastal economies both in terms of food security and by affecting the Good Environmental Status of the marine environment as set out by the European Council’s Marine Strategy Framework Directive (2008/56/EC). Restoration of O. edulis habitat is being widely discussed across Europe, addressing key challenges such as the devastating impact of the haplosporidian parasite Bonamia ostreae. The use of resistant, tolerant, or resilient oysters as restoration broodstock has been proposed by restoration practitioners, but the definitions and implications of these superficially familiar terms have yet to be defined and agreed by all stakeholders. This opinion piece considers the challenges of differentiating Bonamia resistance, tolerance, and resilience; challenges which impede the adoption of robust definitions. We argue that, disease-resistance is reduced susceptibility to infection by the parasite, or active suppression of the parasites ability to multiply and proliferate. Disease-tolerance is the retention of fitness and an ability to neutralise the virulence of the parasite. Disease-resilience is the ability to recover from illness and, at population level, tolerance could be interpreted as resilience. We concede that further work is required to resolve practical uncertainty in applying these definitions, and argue for a collaboration of experts to achieve consensus. Failure to act now might result in the future dispersal of this disease into new locations and populations, because robust definitions are important components of regulatory mechanisms that underpin marine management.