Symmetry Breaking in Homo-Oligomers: The Curious Case of Mega-Hemocyanin
Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the centr...
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| Published in: | Structure (London) Vol. 23; no. 1; pp. 3 - 5 |
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| Abstract | Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits.
Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits. |
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| AbstractList | Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits. Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits. Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits. |
| Author | Steinberg, Avital Levy, Emmanuel D. Garcia Seisdedos, Hector |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25565100$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/185416a0 10.1038/nature04487 10.1021/bi00016a001 10.1016/j.cell.2014.02.034 10.1038/nature06942 10.1016/j.jmb.2007.09.036 10.1371/journal.pone.0036688 10.1110/ps.051658406 10.1016/j.jmb.2008.10.080 10.1016/j.str.2014.10.013 10.1016/j.bbapap.2013.02.020 10.1038/185422a0 |
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| SubjectTerms | Animals Hemocyanins - chemistry Hemocyanins - metabolism Protein Multimerization Snails |
| Title | Symmetry Breaking in Homo-Oligomers: The Curious Case of Mega-Hemocyanin |
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