Symmetry Breaking in Homo-Oligomers: The Curious Case of Mega-Hemocyanin

Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the centr...

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Bibliographic Details
Published in:	Structure (London) Vol. 23; no. 1; pp. 3 - 5
Main Authors:	Garcia Seisdedos, Hector, Steinberg, Avital, Levy, Emmanuel D.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 06-01-2015
Subjects:	Animals Hemocyanins - chemistry Hemocyanins - metabolism Protein Multimerization Snails
Online Access:	Get full text
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Summary:	Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits. Mega-hemocyanin is a 13.5 MDa oxygen transporter found in snails. It is built from three stacked rings involving ten subunits each. The cryo-EM structure of the complex presented by Gatsogiannis and colleagues in this issue of Structure revealed an unexpected breaking of 5-fold symmetry in the central ring and a nonequivalent packing of the subunits.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1
ISSN:	0969-2126 1878-4186
DOI:	10.1016/j.str.2014.12.006