Intra-articular delivery of geraniol encapsulated by pH/redox-responsive nanogel ameliorates osteoarthritis by regulating oxidative stress and inflammation

• Published in: Journal of molecular histology Vol. 54; no. 6; pp. 579 - 591
• Main Authors: Pan, Jun, Cai, Youzhi, Zhang, Chi, Xu, Sanzhong
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-12-2023; Springer Nature B.V
• Subjects: Arthritis; Bioavailability; Biomedical and Life Sciences; Biomedicine; Cartilage; Cartilage diseases; Cell Biology; Chondrocytes; Developmental Biology; FDA approval; Fourier transforms; Histology; Immunohistochemistry; Inflammation; Life Sciences; Oils & fats; Original Paper; Osteoarthritis; Oxidative stress; pH effects; Potassium; Spectrum analysis; Oxidative stress; Inflammation; PH/redox-responsive nanogel; Osteoarthritis; Geraniol
• ISSN: 1567-2379; 1567-2387
• DOI: 10.1007/s10735-023-10163-4

Osteoarthritis (OA) remains a challenging condition due to limited drug bioavailability within the avascular and dense cartilage matrix. This study introduces a pH/redox-responsive nanogel for enhanced delivery of geraniol in OA therapy. We investigated geraniol's role in preventing chondrocyte matrix degradation and designed a pH/redox-responsive nanogel as a delivery platform. Our methods included Western blot, histological staining, and immunohistochemistry. Geraniol treatment reduced Keap1 expression while elevating Nrf2 and HO-1 levels, effectively inhibiting cartilage matrix degradation. The pH/redox-responsive nanogel further enhanced geraniol’s therapeutic impact. Our study demonstrates that geraniol encapsulated within a pH/redox-responsive nanogel mitigates OA by regulating oxidative stress and inflammation. This innovative approach holds potential as an effective OA therapeutic strategy.