Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overvie...

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Published in:	World journal of gastroenterology : WJG Vol. 22; no. 35; pp. 7951 - 7962
Main Authors:	da Silva Oliveira, Kelly Cristina, Thomaz Araújo, Taíssa Maíra, Albuquerque, Camila Inagaki, Barata, Gabriela Alcantara, Gigek, Carolina Oliveira, Leal, Mariana Ferreira, Wisnieski, Fernanda, Rodrigues Mello Junior, Fernando Augusto, Khayat, André Salim, de Assumpção, Paulo Pimentel, Rodriguez Burbano, Rommel Mário, Smith, Marília Cardoso, Calcagno, Danielle Queiroz
Format:	Journal Article
Language:	English
Published:	United States Baishideng Publishing Group Inc 21-09-2016
Subjects:	Biomarkers, Tumor - metabolism Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans MicroRNAs - metabolism MicroRNAs - therapeutic use Polymorphism, Genetic Polymorphism, Single Nucleotide Prognosis Review RNA, Messenger - metabolism Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Prognostic biomarkers Epigenetic Diagnostic biomarkers miRNAs Gastric cancer
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Summary:	Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo; the Conselho Nacional de Desenvolvimento Cientíﬁco e Tecnológico; and the Coordenação de Aperfeiçooamento de Pessoal de Nível Superior. Correspondence to: Danielle Queiroz Calcagno, PhD, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, 2º Piso da UNACON, Av. Mundurucus, Belém, PA 66073-000, Brazil. danicalcagno@gmail.com Author contributions: da Silva Oliveira KC and Calcagno DQ performed the review design; da Silva Oliveira KC, Thomaz Araújo TM, Albuquerque CI and Calcagno DQ collected the data; Thomaz Araújo TM, Albuquerque CI, Barata GA, Rodrigues Mello Junior FA and Calcagno DQ wrote the paper; Gigek CO performed corrections and suggestions; de Assumpção PP, Rodriguez Burbano RM and Smith MC revised the paper critically; all the authors contributed to this manuscript. Telephone: +55-91-32016776
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v22.i35.7951