Computed tomographic colonography with a reduced dose of laxative using a novel barium sulfate contrast agent in Japan

• Published in: Japanese journal of radiology Vol. 37; no. 3; pp. 245 - 254
• Main Authors: Mitsuzaki, Katsuhiko, Iinuma, Gen, Morimoto, Tsuyoshi, Miyake, Mototaka, Tomimatsu, Hideto
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01-03-2019; Springer Nature B.V
• Subjects: Acceptability; Accuracy; Adult; Aged; Barite; Barium; Barium Sulfate; Citric acid; Colon; Colonography, Computed Tomographic - methods; Computation; Computed tomography; Contrast agents; Contrast Media; Effectiveness; Female; Humans; Imaging; Intestine; Japan; Laxatives; Lesions; Magnesium; Male; Marking; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Original Article; Patients; Radiographic Image Enhancement - methods; Radiology; Radiotherapy; Reproducibility of Results; Segments; Sensitivity and Specificity; Sulfates; Surveys and Questionnaires; Japan; Accuracy; Patient acceptance; Computed tomographic colonography (CTC); Tagging efficacy; Barium sulfate
• ISSN: 1867-1071; 1867-108X
• DOI: 10.1007/s11604-018-0800-x

Purpose
To test the tagging efficacy, patient acceptability, and accuracy of computed tomographic colonography (CTC) with a reduced dose of laxative using a novel barium sulfate (BaSO
4
) contrast agent.
Materials and methods
CTC followed by optical colonoscopy (OC) was performed on 73 patients with positive results in fecal occult blood tests. They were administrated a BaSO
4
suspension and a magnesium citrate solution for bowel preparation. Patients completed a questionnaire about the acceptability of bowel preparation. Tagging efficacy was estimated using a novel categorization system, which classified all segments into 8 categories. The accuracy of detecting protruded lesions ≥ 6 mm was calculated from the comparison of CTC and OC results, using the latter as a reference standard.
Results
Tagging efficacy was good in 77.3% of colonic segments where residue was observed. The acceptability of bowel preparation for CTC was significantly higher than that for OC. The sensitivity, specificity, and positive and negative predictive values were 0.778, 0.945, 0.824, and 0.929, respectively. All lesions ≥ 7 mm were successfully detected by CTC.
Conclusion
CTC with a reduced dose of laxative using a novel BaSO
4
contrast agent has a favorable tagging efficacy, patient acceptability, and accuracy.