Successful treatment of meticillin-resistant Staphylococcus aureus bacteraemia in a neonate using daptomycin

• Published in: Journal of medical microbiology Vol. 60; no. 3; pp. 381 - 383
• Main Authors: HUSSAIN, Abid, KAIRAMKONDA, Venkatesh, JERKINS, David Richard
• Format: Journal Article
• Language: English
• Published: Reading Society for General Microbiology 01-03-2011
• Subjects: Anti-Bacterial Agents - therapeutic use; Bacteremia; Bacteremia - drug therapy; Bacteremia - microbiology; Bacterial diseases; Bacterial sepsis; Bacteriology; Biological and medical sciences; daptomycin; Daptomycin - therapeutic use; Data processing; Drug resistance; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Humans; Infant, Newborn; Infection; Infectious diseases; Male; Medical sciences; Methicillin-Resistant Staphylococcus aureus - isolation & purification; Microbiology; Miscellaneous; Neonates; Pediatrics; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcus aureus; Treatment Outcome; Peptides; β-Lactams; Daptomycin; Bacteremia; Meticillin; Penicillin derivatives; Infection; Resistance; Antibiotic; Treatment; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Antibacterial agent; Lipopeptide; Staphylococcus aureus
• ISSN: 0022-2615; 1473-5644
• DOI: 10.1099/jmm.0.027235-0

Daptomycin is licensed for the management of Staphylococcus aureus infections in adults, including those caused by meticillin-resistant S. aureus (MRSA). Few data exist on paediatric use or dose guidance in neonates. We report the case of a neonate with MRSA bacteraemia successfully managed with daptomycin. Dose requirements were substantially higher than those recommended for adults.