Mechanisms of Cardiac Repair in Cell Therapy

Heart failure is an important cause of morbidity and mortality. More than 20 years ago, special interest was drawn to cell therapy as a means of restoring damaged hearts to working condition. But progress has not been straightforward as many of our initial assumptions turned out to be wrong. In this...

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Bibliographic Details
Published in:	Heart, lung & circulation Vol. 32; no. 7; pp. 825 - 835
Main Authors:	Collet, Bérénice C, Davis, Darryl R
Format:	Journal Article
Language:	English
Published:	Australia 01-07-2023
Subjects:	Cell- and Tissue-Based Therapy Heart - physiology Heart Failure - therapy Humans Myocytes, Cardiac Regeneration Heart failure Myocardial infarction Regeneration Cell therapy
Online Access:	Get full text
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Summary:	Heart failure is an important cause of morbidity and mortality. More than 20 years ago, special interest was drawn to cell therapy as a means of restoring damaged hearts to working condition. But progress has not been straightforward as many of our initial assumptions turned out to be wrong. In this review, we critically examine the last 20 years of progress in cardiac cell therapy and focus on several of the popular beliefs surrounding cell therapy to illustrate the mechanisms involved in restoring heart function after cardiac injury. Are they true or false?
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1443-9506 1444-2892
DOI:	10.1016/j.hlc.2023.01.019