Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students

• Published in: Frontiers in genetics Vol. 8; p. 30
• Main Authors: Webb, Bradley T, Edwards, Alexis C, Wolen, Aaron R, Salvatore, Jessica E, Aliev, Fazil, Riley, Brien P, Sun, Cuie, Williamson, Vernell S, Kitchens, James N, Pedersen, Kimberly, Adkins, Amy, Cooke, Megan E, Savage, Jeanne E, Neale, Zoe, Cho, Seung B, Dick, Danielle M, Kendler, Kenneth S
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15-03-2017
• Subjects: Genetics; alcohol problems; genetic ancestry; GWAS; alcohol consumption; genome-wide polygenic score; heritability
• ISSN: 1664-8021; 1664-8021
• DOI: 10.3389/fgene.2017.00030

Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk.
We conducted genome-wide association studies (GWAS) in an ethnically diverse sample of college students for three quantitative outcomes including typical monthly alcohol consumption, alcohol problems, and maximum number of drinks in 24 h. Heritability based on common genetic variants (
) was assessed. We also evaluated whether risk variants in aggregate were associated with alcohol use outcomes in an independent sample of young adults.
Two genome-wide significant markers were observed: rs11201929 in
for maximum drinks in 24 h, with supportive evidence across all ancestry groups; and rs73317305 in
(alcohol problems), tested only in the African ancestry group. The
estimate was 0.19 (SE = 0.11) for consumption, and was non-significant for other outcomes. Genome-wide polygenic scores were significantly associated with alcohol outcomes in an independent sample.
These results robustly identify genetic risk for alcohol use outcomes at the variant level and in aggregate. We confirm prior evidence that genetic variation in
impacts alcohol use, and identify novel loci of interest for multiple alcohol outcomes in emerging adults. These findings indicate that genetic variation influencing normative and problematic alcohol use is, to some extent, convergent across ancestry groups. Studying college populations represents a promising avenue by which to obtain large, diverse samples for gene identification.