Challenges in diagnosis and management of adult spinal cord gliomas

Intramedullary spinal cord gliomas have very low incidence rates. They are associated with difficulties in diagnosis and treatment, and cause significant morbidity. Their clinical presentation and their appearance at magnetic resonance imaging are not specific. They can mimic inflammatory, infectiou...

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Bibliographic Details
Published in:	Revue neurologique Vol. 177; no. 5; pp. 515 - 523
Main Authors:	Campello, C., Tabouret, E., Chinot, O.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-05-2021 Elsevier Masson
Subjects:	Astrocytoma Ependymoma Life Sciences Magnetic resonance imaging Molecular markers Spinal cord glioma Molecular markers Magnetic resonance imaging Spinal cord glioma Ependymoma Astrocytoma
Online Access:	Get full text
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Summary:	Intramedullary spinal cord gliomas have very low incidence rates. They are associated with difficulties in diagnosis and treatment, and cause significant morbidity. Their clinical presentation and their appearance at magnetic resonance imaging are not specific. They can mimic inflammatory, infectious, vascular disorders or other neoplastic lesions. Primary treatment is surgery. Surgical resection can often be total for ependymomas, but difficult for infiltrating astrocytomas. Radiotherapy is indicated for malignant tumors, but remains controversial in some indications. Chemotherapy is reserved for recurrence, but small retrospective series are available. Genetic studies have revealed genetic alterations which could have a potential impact on treatment in the near future.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0035-3787
DOI:	10.1016/j.neurol.2021.02.384