Genetic relationship between the Echinococcus granulosus sensu stricto cysts located in lung and liver of hosts

• Published in: Infection, genetics and evolution Vol. 44; pp. 356 - 360
• Main Authors: Oudni-M'rad, Myriam, Cabaret, Jacques, M'rad, Selim, Chaâbane-Banaoues, Raja, Mekki, Mongi, Zmantar, Sofien, Nouri, Abdellatif, Mezhoud, Habib, Babba, Hamouda
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-10-2016; Elsevier
• Subjects: Alleles; Animal biology; Animals; Cattle; Disease Susceptibility; Echinococcosis, Hepatic - parasitology; Echinococcosis, Hepatic - pathology; Echinococcosis, Pulmonary - parasitology; Echinococcosis, Pulmonary - pathology; Echinococcus granulosus; Echinococcus granulosus - classification; Echinococcus granulosus - genetics; G1 genotype; Genetic Loci; Genetic Variation; Genotype; Host-Parasite Interactions; Humans; Life Sciences; Linkage Disequilibrium; Liver; Lung; Microbiology and Parasitology; Phylogeny; Protozoan Infections, Animal - parasitology; Protozoan Infections, Animal - pathology; Sheep; Veterinary medicine and animal Health; Genetic variation; Lung; Liver; Echinococcus granulosus; G1 genotype
• ISSN: 1567-1348; 1567-7257
• DOI: 10.1016/j.meegid.2016.07.024

G1 genotype of Echinococcus granulosus sensu stricto is the major cause of hydatidosis in Northern Africa, Tunisia included. The genetic relationship between lung and liver localization were studied in ovine, bovine and human hydatid cysts in Tunisia. Allozyme variation and single strand conformation polymorphism were used for genetic differentiation. The first cause of genetic differentiation was the host species and the second was the localization (lung or liver). The reticulated genetic relationship between the liver or the lung human isolates and isolates from bovine lung, is indicative of recombination (sexual reproduction) or lateral genetic transfer. The idea of two specialized populations (one for the lung one for the liver) that are more or less successful according to host susceptibility is thus proposed.
•Genetic relationship between lung and liver localization of hydatid cysts.•The genetic differentiation was due to the host species and the cyst localization.•The lung and liver isolates from G1 genotype were clearly different.•There are two specialized populations that are more or less successful according to host susceptibility.