Initial report of bladder carcinoma following combined bladder‐drained pancreas and kidney transplantation

• Published in: Clinical transplantation Vol. 16; no. 5; pp. 383 - 386
• Main Authors: Highshaw, Ralph A, Tunuguntla, Hari SGR, Perez, Richard V, Gandour‐Edwards, Regina, Evans, Christopher P
• Format: Journal Article
• Language: English
• Published: Oxford UK Munksgaard International Publishers 01-10-2002; Blackwell
• Subjects: adeno‐squamous carcinoma; Adult; Biological and medical sciences; carcinogenesis; Carcinoma, Adenosquamous - complications; Carcinoma, Adenosquamous - etiology; cytology; Diabetes Mellitus, Type 1 - complications; Female; hematuria; Humans; kidney; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - surgery; Kidney Transplantation - adverse effects; Kidney Transplantation - methods; Medical sciences; Nephrology. Urinary tract diseases; pancreas transplantation; Pancreas Transplantation - adverse effects; Pancreas Transplantation - methods; transitional cell carcinoma; Tumors of the urinary system; Urinary Bladder Neoplasms - complications; Urinary Bladder Neoplasms - etiology; Urinary Bladder Neoplasms - therapy; Urinary tract. Prostate gland; Human; Adenosquamous carcinoma; Urinary system disease; Carcinoma; Transplantation; Urinary tract disease; Malignant tumor; Kidney; Case study; Urinary bladder; Surgery; Complication; Bladder disease; Pancreas
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1034/j.1399-0012.2002.02034.x

Highshaw RA, Tunuguntla HSGR, Perez RV, Gandour‐Edwards R, Evans CP. Initial report of bladder carcinoma following combined bladder‐drained pancreas and kidney transplantation. Clin Transplant 2002: 16: 383–386. © Blackwell Munksgaard, 2002
Although long‐term survival of a functional allograft requiring long‐term immunosuppressive therapy is responsible for higher incidence of non‐urothelial cancers in renal allograft recipients than in normal population, the incidence of bladder cancer is uncommon and carcinoma of the bladder in the setting of combined kidney–pancreas transplantation has not been reported to date. We herein report a case of poorly differentiated invasive adeno‐squamous cell carcinoma of the bladder following renal and bladder‐drained pancreatic transplantation in a 44‐yr‐old lady with long‐standing insulin dependent diabetes mellitus, which necessitated radical extirpation. Management implications are reviewed.