Feasibility of dynamic susceptibility contrast perfusion MR imaging at 3T using a standard quadrature head coil and eight-channel phased-array coil with and without SENSE reconstruction

• Published in: Journal of magnetic resonance imaging Vol. 24; no. 3; pp. 520 - 529
• Main Authors: Lupo, Janine M., Lee, Michael C., Han, Eric T., Cha, Soonmee, Chang, Susan M., Berger, Mitchel S., Nelson, Sarah J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-09-2006
• Subjects: Adult; Aged; Aged, 80 and over; Brain - pathology; Brain Neoplasms - diagnosis; Brain Neoplasms - pathology; distortion; Echo-Planar Imaging; EPI; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Middle Aged; perfusion imaging; SENSE; Sensitivity and Specificity; SNR; Time Factors
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.20673

Purpose
To investigate changes in image and dynamic signal‐to‐noise ratios (SNRs) of the ΔR2* curve, as well as magnetic susceptibility‐induced artifacts between a standard quadrature head coil and an eight‐channel phased‐array coil with and without sensitivity‐encoding (SENSE) at 3T, compared to the current clinical standard head coil acquisition at 1.5T.
Materials and Methods
Dynamic susceptibility contrast (DSC) perfusion MRI was performed on 80 brain tumor patients using a gradient‐echo, echo‐planar imaging (EPI) sequence. Image and dynamic SNR were compared between 1.5T and 3T field strengths, a quadrature and eight‐channel phased‐array coil, and a conventional vs. partially parallel EPI acquisition with SENSE reconstruction. The amount of geometric distortion and signal dropout was quantified and compared between conventional and SENSE EPI acquisitions within the same exam at 3T.
Results
An initial 2.6‐fold elevation in dynamic SNR was observed in normal‐appearing white matter when doubling the field strength (P < 0.001), with an additional 1.7‐fold increase found when employing an eight‐channel phased‐array coil (P < 0.002). Compared to the standard 3T eight‐channel coil acquisition, the implementation of SENSE reduced the number of voxels experiencing large anterior shifts in the phase‐encode direction, lowered the volume of signal dropout by 2.0–11.5%, and allowed a 1.4‐fold increase in slice coverage, while only decreasing the dynamic SNR by 22%.
Conclusion
SENSE EPI at 3T yielded a significant improvement in dynamic SNR over the 1.5T acquisitions. A significant reduction in magnetic susceptibility‐induced artifacts was achieved with SENSE EPI compared to the standard EPI eight‐channel coil acquisition at 3T. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.